Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Corpora amylacea act as containers that remove waste products from the brain

by Ximelis, Teresa , Ferrer, Ruth , Pelegrí, Carme , Moral-Anter, David , Vilaplana, Jordi , Campo-Sabariz, Joan , Augé, Elisabet , Molina-Porcel, Laura , Riba, Marta , Martín-Venegas, Raquel

in Aged / Aged, 80 and over / Aging / Astrocytes / Astrocytes - immunology / Astrocytes - metabolism / Biological Sciences / Brain / Brain - pathology / Brain diseases / Cerebrospinal fluid / Containers / Glymphatic System / Humans / Immune system / Inclusion Bodies - immunology / Inclusion Bodies - metabolism / Lymph Nodes / Lymphatic System / Macrophages / Neurodegenerative Diseases - immunology / Neurodegenerative Diseases - metabolism / Neurodegenerative Diseases - pathology / Phagocytosis / Physiology / THP-1 Cells / Waste Products

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Corpora amylacea act as containers that remove waste products from the brain

by Ximelis, Teresa , Ferrer, Ruth , Pelegrí, Carme , Moral-Anter, David , Vilaplana, Jordi , Campo-Sabariz, Joan , Augé, Elisabet , Molina-Porcel, Laura , Riba, Marta , Martín-Venegas, Raquel

2019

Confirm

Do you wish to request the book?

Corpora amylacea act as containers that remove waste products from the brain

by Ximelis, Teresa , Ferrer, Ruth , Pelegrí, Carme , Moral-Anter, David , Vilaplana, Jordi , Campo-Sabariz, Joan , Augé, Elisabet , Molina-Porcel, Laura , Riba, Marta , Martín-Venegas, Raquel

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Corpora amylacea act as containers that remove waste products from the brain

Ximelis, Teresa,

Ferrer, Ruth,

Pelegrí, Carme,

Moral-Anter, David,

Vilaplana, Jordi,

Campo-Sabariz, Joan,

Augé, Elisabet,

Molina-Porcel, Laura,

Riba, Marta,

Martín-Venegas, Raquel

2019

Overview

Corpora amylacea (CA) in the human brain are granular bodies formed by polyglucosan aggregates that amass waste products of different origins. They are generated by astrocytes, mainly during aging and neurodegenerative conditions, and are located predominantly in periventricular and subpial regions. This study shows that CA are released from these regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that may aid in the diagnosis of certain brain diseases.

Share this book

Add to My Shelf

Publisher

National Academy of Sciences

Subject

Aged

/ Aged, 80 and over

/ Aging

/ Astrocytes

/ Astrocytes - immunology

/ Astrocytes - metabolism

/ Biological Sciences