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Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

by Gillatt, David , Blazeby, Jane M , Peters, Tim J , Lennon, Teresa , Gray, Catherine , Bollina, Prasad , Metcalfe, Chris , Cooper, Deborah , Lane, J. Athene , Bonnington, Susan , Howson, Joanne , Herbert, Phillipa , Tidball, Sarah , Thompson, Pauline , Blaikie, Jan , Catto, James , Martin, Richard M , Lyons, Norma , Rosario, Derek J , Kynaston, Howard , Davis, Michael , Bradshaw, Lynne , Kockelbergh, Roger , Holding, Peter , Walsh, Eleanor , Salter, Elizabeth , Doble, Andrew , Turner, Emma L , Prescott, Stephen , Neal, David E , Powell, Philip , Donovan, Jenny L , Jones, Amanda , Paul, Alan , Hamdy, Freddie C , Doherty, Alan , Mason, Malcolm , Rowe, Edward

in Aged / Anxiety / Cancer surgery / Clinical outcomes / Clinical trials / Comparative studies / Data processing / Digestive System Diseases / Erectile Dysfunction / Health Status / Humans / Intention to Treat Analysis / Intestine / Male / Mental depression / Middle Aged / Motivation / Outcome Assessment, Health Care / Patients / Prostate cancer / Prostatectomy / Prostatic Neoplasms - mortality / Prostatic Neoplasms - radiotherapy / Prostatic Neoplasms - surgery / Prostatic Neoplasms - therapy / Quality of Life / Radiation therapy / Surgery / Surveys and Questionnaires / Treatment Outcome / Urologic Diseases / Urological surgery / Watchful Waiting

2016

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2016

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2016

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Journal Article

Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer

Gillatt, David,

Blazeby, Jane M,

Peters, Tim J,

Lennon, Teresa,

Gray, Catherine,

Bollina, Prasad,

Metcalfe, Chris,

Cooper, Deborah,

Lane, J. Athene,

Bonnington, Susan,

Howson, Joanne,

Herbert, Phillipa,

Tidball, Sarah,

Thompson, Pauline,

Blaikie, Jan,

Catto, James,

Martin, Richard M,

Lyons, Norma,

Rosario, Derek J,

Kynaston, Howard,

Davis, Michael,

Bradshaw, Lynne,

Kockelbergh, Roger,

Holding, Peter,

Walsh, Eleanor,

Salter, Elizabeth,

Doble, Andrew,

Turner, Emma L,

Prescott, Stephen,

Neal, David E,

Powell, Philip,

Donovan, Jenny L,

Jones, Amanda,

Paul, Alan,

Hamdy, Freddie C,

Doherty, Alan,

Mason, Malcolm,

Rowe, Edward

2016

Overview

The choice of treatment for PSA-detected, localized prostate cancer is influenced by effects of the interventions on quality of life. In the ProtecT trial, patterns of side-effect severity, improvement, and decline in urinary, sexual, and bowel function differed among the treatments. As reported in a companion article in the Journal, the U.K. National Institute for Health Research–supported Prostate Testing for Cancer and Treatment (ProtecT) trial has shown no significant difference in prostate-cancer–specific mortality or all-cause mortality among men with prostate cancer detected by prostate-specific antigen (PSA) testing who were randomly assigned to radical prostatectomy, active monitoring (a surveillance strategy), or radical conformal radiotherapy with neoadjuvant hormonal therapy, at a median of 10 years of follow-up; however, the ProtecT trial has shown higher rates of metastases and disease progression among men in the active-monitoring group than among men in the radical-treatment groups. . . .

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Publisher

Massachusetts Medical Society

Subject

/ Anxiety

/ Comparative studies

/ Data processing