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Evolution of short sequence repeats in Mycobacterium tuberculosis
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Evolution of short sequence repeats in Mycobacterium tuberculosis
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Journal Article
Evolution of short sequence repeats in Mycobacterium tuberculosis
2006
Overview
Abstract
Whole genome comparison has revealed the presence of short sequence repeats (also called mycobacterial interspersed repeat units and variable number tandem repeat units) used for genotyping schemes. In this study, we have used deletion analysis, single nucleotide polymorphism data and spoligotype taken from published data from others to investigate the evolution of selected repeats that form the common denominators of the majority of established schemes. Analysis of the number of repeats per locus from over 400 isolates revealed that the general trend globally appears to be loss of repeats in modern strains compared with ancestral strains.
Publisher
Blackwell Publishing Ltd,Blackwell Science Ltd,Blackwell,Oxford University Press
