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CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
by Marina Kleanthous , Yukio Nakamura , Panayiota L. Papasavva , Constantinos C. Loucari , Petros Patsali , Carsten W. Lederer , Ryo Kurita
in 3' Untranslated Regions / Cell Line / CRISPR-Cas Systems / DNA End-Joining Repair / Erythroid Cells / Gene Editing / gene tagging; cell/tissue-type-specific gene therapy; γ-globin induction; hemoglobinopathies; BCL11A; erythroid-specific; HUDEP-2 cells; CD34+ cells / HEK293 Cells / Humans / MicroRNAs / Proof of Concept Study / Repressor Proteins
2022
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CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
by Marina Kleanthous , Yukio Nakamura , Panayiota L. Papasavva , Constantinos C. Loucari , Petros Patsali , Carsten W. Lederer , Ryo Kurita
in 3' Untranslated Regions / Cell Line / CRISPR-Cas Systems / DNA End-Joining Repair / Erythroid Cells / Gene Editing / gene tagging; cell/tissue-type-specific gene therapy; γ-globin induction; hemoglobinopathies; BCL11A; erythroid-specific; HUDEP-2 cells; CD34+ cells / HEK293 Cells / Humans / MicroRNAs / Proof of Concept Study / Repressor Proteins
2022
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CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
by Marina Kleanthous , Yukio Nakamura , Panayiota L. Papasavva , Constantinos C. Loucari , Petros Patsali , Carsten W. Lederer , Ryo Kurita
in 3' Untranslated Regions / Cell Line / CRISPR-Cas Systems / DNA End-Joining Repair / Erythroid Cells / Gene Editing / gene tagging; cell/tissue-type-specific gene therapy; γ-globin induction; hemoglobinopathies; BCL11A; erythroid-specific; HUDEP-2 cells; CD34+ cells / HEK293 Cells / Humans / MicroRNAs / Proof of Concept Study / Repressor Proteins
2022

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CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation
Journal Article

CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation

Marina Kleanthous,
Yukio Nakamura,
Panayiota L. Papasavva,
Constantinos C. Loucari,
Petros Patsali,
Carsten W. Lederer,
Ryo Kurita
2022
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Publisher
MDPI AG
Subject

3' Untranslated Regions

/ Cell Line

/ CRISPR-Cas Systems

/ DNA End-Joining Repair

/ Erythroid Cells

/ Gene Editing

/ gene tagging; cell/tissue-type-specific gene therapy; γ-globin induction; hemoglobinopathies; BCL11A; erythroid-specific; HUDEP-2 cells; CD34+ cells

/ HEK293 Cells

/ Humans

/ MicroRNAs

/ Proof of Concept Study

/ Repressor Proteins

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