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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus
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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus
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Journal Article
Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus
2001
Overview
A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 Å resolution crystal structure of the
Sulfolobus solfataricus
Dbh protein, a DNA translesion polymerase closely related to
Escherichia coli
DNA polymerase IV and human polymerase κ. A high error rate is observed for the Dbh polymerase in a range of 10
−2
–10
−3
for all 12 base substitution mispairs. The crystal structure of Dbh reveals an overall architecture resembling other DNA polymerases but has unique features that are likely to contribute to error-prone synthesis, including −1 frameshifting mutations.
Publisher
Nature Publishing Group US,Nature Publishing Group
