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Maternal Transfer of Vaccine-Induced Anti-OspA Antibodies in Peromyscus spp Protects Pups from Tick-Transmitted Borrelia burgdorferi
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Maternal Transfer of Vaccine-Induced Anti-OspA Antibodies in Peromyscus spp Protects Pups from Tick-Transmitted Borrelia burgdorferi
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Maternal Transfer of Vaccine-Induced Anti-OspA Antibodies in Peromyscus spp Protects Pups from Tick-Transmitted Borrelia burgdorferi
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Paper
Maternal Transfer of Vaccine-Induced Anti-OspA Antibodies in Peromyscus spp Protects Pups from Tick-Transmitted Borrelia burgdorferi
2025
Overview
Maternal antibody transfer provides passive immunity to offspring; however, the efficacy and duration of this protection depends on maternal antibody levels and transfer efficiency. We investigated whether oral vaccination of Peromyscus leucopus dams with recombinant OspA-expressing E. coli could induce maternal transfer of anti-OspA antibodies and protect pups from Borrelia burgdorferi challenge. Dams were vaccinated for different durations: (i) until breeding, (ii) until birth of pups, or (iii) until pups were 2 weeks old. Pups were challenged with Ixodes scapularis nymph-transmitted B. burgdorferi at ~ 4 weeks of age. Anti-OspA IgG were quantified in dams and pups, and B. burgdorferi anti-PepVF IgG were quantified in pups. Furthermore, B. burgdorferi burden was assessed by qPCR targeting the flaB gene in pups’ heart and bladder tissues > 4 weeks after tick challenge. P. leucopus pups born to dams vaccinated until breeding, exhibited low anti-OspA antibody and were not protected from tick transmitted B. burgdorferi infection. However, when maternal vaccination extended until pups were born and until pups were two weeks old, significant anti-OspA antibody transfer and protection occurred. This was evidenced by absence of antibody to B. burgdorferi PepVF, absence of B. burgdorferi flaB DNA in heart and bladder tissues, and absence of flaB in culture from heart tissues from pups euthanized >9 weeks after birth. We show that transfer of anti-OspA antibodies from P. leucopus dams to offspring prevents tick transmission of B. burgdorferi in the major reservoir host of this spirochete in the United States.
Publisher
Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
Subject
