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Holdase activity of secreted Hsp70 masks amyloid- beta 42 neurotoxicity in Drosophila
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Holdase activity of secreted Hsp70 masks amyloid- beta 42 neurotoxicity in Drosophila
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Holdase activity of secreted Hsp70 masks amyloid- beta 42 neurotoxicity in Drosophila
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Journal Article
Holdase activity of secreted Hsp70 masks amyloid- beta 42 neurotoxicity in Drosophila
2016
Overview
Alzheimer's disease (AD) is the most prevalent of a large group of related proteinopathies for which there is currently no cure. Here, we used Drosophila to explore a strategy to block A beta 42 neurotoxicity through engineering of the Heat shock protein 70 (Hsp70), a chaperone that has demonstrated neuroprotective activity against several intracellular amyloids. To target its protective activity against extracellular A beta 42, we added a signal peptide to Hsp70. This secreted form of Hsp70 (secHsp70) suppresses A beta 42 neurotoxicity in adult eyes, reduces cell death, protects the structural integrity of adult neurons, alleviates locomotor dysfunction, and extends lifespan. SecHsp70 binding to A beta 42 through its holdase domain is neuroprotective, but its ATPase activity is not required in the extracellular space. Thus, the holdase activity of secHsp70 masks A beta 42 neurotoxicity by promoting the accumulation of nontoxic aggregates. Combined with other approaches, this strategy may contribute to reduce the burden of AD and other extracellular proteinopathies.
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