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肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析
肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析
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肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析
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肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析
肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析

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肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析
肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析
Journal Article

肝硬化及肝细胞癌患者腰肌横向厚度指数与营养风险的相关性分析

2020
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Overview
摘要:目的探究肝硬化及肝细胞癌患者腰肌橫向厚度指数 (TPTI) 与患者发生营养风险的相关性。方法选取2018年1月-2019年1月于天津市第三中心医院住院,并行腹部CT的肝硬化及肝细胞癌患者共151例,根据纳入及排除标准筛选研究对象,分为单纯肝硬化组 (n=95) 和肝细胞癌组 (n=56) 。应用营养风险筛查2002 (NRS-2002) 将肝硬化、肝细胞癌患者分别分为有营养风险组、无营养风险组。收集身高、体质量、肝功能及TPTI等临床数据。计量资料两组间比较采用t检验或Mann-Whitney U检验,计数资料两组间比较采用χ2检验、趋势χ2检验。采用logistic回归分析肝硬化及肝细胞癌患者发生营养风险的相关因素。结果Child-Pugh A级、B级、C级单纯肝硬化患者营养风险发生率分别为61.2%、80.6%、86.7%,肝细胞癌患者营养风险发生率分别为44.4%、84.6%、85.7%。趋势χ2检验及Spearman相关分析显示,随着肝功能储备下降,肝硬化、肝细胞癌患者营养风险发生率呈上升趋势 (χ2=5.051,P=0.025;r=0.388,P=0.003) 。肝硬化及肝细胞癌患者的TPTI值在有营养风险组患者中均显著低于无营养风险组患者 (P值均<0.05) 。肝硬化组患者中,logistic回归模型调整Alb水平后,TPTI值越高,患者发生营养风险的可能性越低 (比值比=0.766,95%可信区间:0.642~0.915) 。结论随着肝功能储备下降,肝硬化及肝细胞癌患者营养风险发生率呈上升趋势。肝硬化患者中,TPTI值越高,患者发生营养风险的可能性越低。肝细胞癌患者中,有营养风险的患者TPTI值较低。
Publisher
Journal of Clinical Hepatology,天津市肝胆疾病研究所,天津300170,天津市人工细胞重点实验室,天津300170,卫生部人工细胞工程技术研究中心,天津300170,天津医科大学三中心临床学院,天津300170%天津市第三中心医院 营养科,天津300170%天津市第三中心医院 放射科,天津300170%天津医科大学三中心临床学院,天津300170,天津市第三中心医院 肝内科,天津300170