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Dapsone drug resistance in the MDT era
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Journal Article
Dapsone drug resistance in the MDT era
2000
Overview
In Nepal, dapsone (DDS) monotherapy was introduced in 1956 and MDT in 1983, although the coverage of MDT only reached 95% more than a decade later. Since 1987, we have been testing all suitable patients for primary and secondary drug resistance using the mouse foot pad model. We have analyzed the drug sensitivities of Mycobacterium leprae isolated from skin biopsies from 268 new and relapsed cases and from patients re-starting treatment. In the period 1988 to 1999, there was a decline in the prevalence of acquired dapsone resistance and a rise in the prevalence of primary dapsone resistance. There was a complete absence of rifampin (RMP) resistance among our patients.
Publisher
Allen Press,International Leprosy Association
Subject
/ Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Biological and medical sciences
/ Clofazimine - administration & dosage
/ Clofazimine - therapeutic use
/ Dapsone - administration & dosage
/ Humans
/ Leprostatic Agents - administration & dosage
/ Leprostatic Agents - pharmacology
/ Leprostatic Agents - therapeutic use
/ Mycobacterium leprae - drug effects
/ Nepal
/ Pharmacology. Drug treatments
