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Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches
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Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches
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Journal Article
Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches
2020
Overview
commonly known as goldenseal, is a botanical native to the southeastern United States that has been used for the treatment of infection. The activity of goldenseal is often attributed to the presence of alkaloids (cyclic, nitrogen-containing compounds) present within its roots. Chemical components of botanical supplements like goldenseal may face degradation if not stored properly. The purpose of the research was to analyze the stability of known and unknown metabolites of
during exposure to different storage conditions using mass spectrometry. Three abundant metabolites of
, berberine, canadine, and hydrastine, were chosen for targeted analysis, and the stability of unknown metabolites was evaluated using untargeted metabolomics. The analysis and evaluation of
samples were performed utilizing LC-MS and Principal Component Analysis (PCA). The research project focused on identifying the chemical changes in the metabolite content of
under different temperature conditions (40°C ± 5°C, 20°C ± 5°C , and 4°C ± 5°C), different light:dark (hr:hr) cycles (16:8, 12:12, and 0:24), and different sample conditions (powdered roots versus whole roots) over a six month period. The results of this 6-month study revealed that the storage conditions evaluated had no significant effects on the chemical composition of
roots. Hence, as long as
roots are stored within the storage conditions tested in the study, no significant changes in chemical compositions of metabolites are expected.
Publisher
Yale Journal of Biology and Medicine,YJBM
Subject
Benzylisoquinolines - analysis
/ Berberine - analogs & derivatives
/ Berberine Alkaloids - analysis
/ Berberine Alkaloids - pharmacology
/ Gas flow
/ Humans
/ Plant Preparations - chemistry
/ Plant Preparations - pharmacology
/ Principal Component Analysis - methods
/ Principal components analysis
/ Roots
/ Software
