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Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

by Gamal, Maha Mohamed , Rashed, Laila Ahmed , Esmail, Reham Shehab El Nemr , Amin, Shaimaa Nasr , Elberry, Dalia Azmy

in Actin / Alanine transaminase / Animal models / Apoptosis / BAX protein / Bcl-2 protein / Cell differentiation / Cirrhosis / Cognitive ability / Dopamine receptors / Gene expression / Glial fibrillary acidic protein / Hepatic encephalopathy / Hepatocyte growth factor / Hepatocytes / Liver / Mesenchymal stem cells / Open-field behavior / Original / Smooth muscle / Synaptophysin / Thioacetamide / Transforming growth factor-b1

2016

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Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

by Gamal, Maha Mohamed , Rashed, Laila Ahmed , Esmail, Reham Shehab El Nemr , Amin, Shaimaa Nasr , Elberry, Dalia Azmy

2016

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Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

by Gamal, Maha Mohamed , Rashed, Laila Ahmed , Esmail, Reham Shehab El Nemr , Amin, Shaimaa Nasr , Elberry, Dalia Azmy

2016

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Journal Article

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

Gamal, Maha Mohamed,

Rashed, Laila Ahmed,

Esmail, Reham Shehab El Nemr,

Amin, Shaimaa Nasr,

Elberry, Dalia Azmy

2016

Overview

Liver cirrhosis is the outcome of chronic liver injury. The current study aimed to investigate the therapeutic effect of undifferentiated mesenchymal stem cells versus partially differentiated mesenchymal stem cells on liver cirrhosis and hepatic encephalopathy. 50 adult male albino rats constituted the animal model and were divided into the following groups: control, thioacetamide, undifferentiated mesenchymal stem cells and hepatocyte growth factor-differentiated mesenchymal stem cells groups. Cognitive assessment was achieved by open field test and Y-maze task. We measured serum alanine aminotransferase, albumin and transforming growth factor-beta1, gene expression of α-smooth muscle actin, matrix metalloprotein-2, its tissue inhibitor and apoptotic markers: Bax and Bcl2, brain glial fibrillary acidic protein, synaptophysin, and dopaminergic receptors.

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Publisher

EXCLI Journal,Leibniz Research Centre for Working Environment and Human Factors

Subject

Actin

/ Alanine transaminase

/ Cell differentiation