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Rottlerin Inhibits ROS Formation and Prevents NFkappa B Activation in MCF-7 and HT-29 Cells
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Rottlerin Inhibits ROS Formation and Prevents NFkappa B Activation in MCF-7 and HT-29 Cells
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Journal Article
Rottlerin Inhibits ROS Formation and Prevents NFkappa B Activation in MCF-7 and HT-29 Cells
2009
Overview
Rottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKC δ , although it can inhibit many kinases and has several biological effects. Among them, we recently found that Rottlerin inhibits the Nuclear Factor κ B (NFκ B), activated by either phorbol esters or [subscript]H2[/subscript] [subscript]O2[/subscript] . Because of the redox sensitivity of NFκ B and on the basis of Rottlerin antioxidant property, we hypothesized that Rottlerin could prevent NFκ B activation acting as a free radicals scavenger, as other natural polyphenols. The current study confirms the antioxidant property of Rottlerin against the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) in vitro and against oxidative stress induced by [subscript]H2[/subscript] [subscript]O2[/subscript] and by menadione in culture cells. We also demonstrate that Rottlerin prevents TNFα -dependent NFκ B activation in MCF-7 cells and in HT-29 cells transfected with the NFκ B-driven plasmid pBIIX-LUC, suggesting that Rottlerin can inhibit NFκ B via several pathways and in several cell types.
Publisher
John Wiley & Sons, Inc
Subject
