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术前恶性不除外手术病理确诊肺部良性病变297例患者临床-放射-病理特征分析:一项中国单中心回顾性队列研究
by
留永健
, 梁红格
, 石岳泉
, 王孟昭
, 李单青
, 周晴
, 徐燕
, 郭超
, 陈闽江
, 刘洪生
, 蒋德利娜
, 赵静
, 高晓星
, 叶秋月
, 钟巍
, 刘潇衍
in
Clinical Research
/ 临床研究
2020
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术前恶性不除外手术病理确诊肺部良性病变297例患者临床-放射-病理特征分析:一项中国单中心回顾性队列研究
by
留永健
, 梁红格
, 石岳泉
, 王孟昭
, 李单青
, 周晴
, 徐燕
, 郭超
, 陈闽江
, 刘洪生
, 蒋德利娜
, 赵静
, 高晓星
, 叶秋月
, 钟巍
, 刘潇衍
in
Clinical Research
/ 临床研究
2020
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Journal Article
术前恶性不除外手术病理确诊肺部良性病变297例患者临床-放射-病理特征分析:一项中国单中心回顾性队列研究
留永健,
梁红格,
石岳泉,
王孟昭,
李单青,
周晴,
徐燕,
郭超,
陈闽江,
刘洪生,
蒋德利娜,
赵静,
高晓星,
叶秋月,
钟巍,
2020
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Overview
背景与目的 随着癌症早筛意识的提高,低剂量计算机断层扫描(low-dose computed tomography,LDCT)用于肺癌筛查在中国广泛开展.尽管有部分胸部LDCT筛查所见的肺部病灶是肿瘤病灶,但大多数的肺部结节是良性病变.如何有效的对肺部病灶进行术前鉴别,如何降低部分可避免手术的良性疾病的手术切除比例,是需要关注的问题.方法 本研究纳入2017年1月1日-2018年12月31日期间北京协和医院诊治的,术前考虑肺部恶性病变不能除外,经手术病理确认为良性病变的患者,回顾性分析患者临床信息.结果 297例患者纳入本研究,占我院肺部病灶行肺部手术治疗患者的9.8%.197例(66.3%)患者因体检行LDCT筛查发现肺部病灶.肺部病变胸部CT影像学评估情况,可评估的323个病灶,平均长径为(17.9±12.1)mm,直径≥8 mm的占91.0%,实性最多见(212/323,65.6%),此类肺部病灶可有毛刺征(71/323,22.0%)、分叶征(94/323,29.1%)、胸膜牵拉征(81/323,25.1%)、血管集束征(130/323,40.2%)、空泡征(23/323,7.1%)等,提示恶性病变的影像学特征.292例(98.3%)行电视辅助胸腔镜手术(video-assisted thoracoscopic surgery,VATS),232例(78.1%)患者行肺楔形切除术,13例(4.4%)行肺段切除术,51例(17.2%)患者行肺叶切除术.4例(1.3%)患者出现手术并发症.术后病理类型前3位的是感染性疾病98例(33.0%)、炎性结节96例(32.3%)和错构瘤64例(21.5%).结论 因术前不能排除恶性而行手术切除的肺部良性病灶,影像学表现以实性病灶多见,但多具有提示恶性的影像学特征.VATS可作为一种明确病原病理的重要活检方式.此类病灶病理结果以感染性疾病和炎性结节最为常见,错构瘤第三.
Publisher
100730 北京,中国医学科学院,北京协和医学院,北京协和医院呼吸与危重症医学科%100730 北京,中国医学科学院,北京协和医学院,北京协和医院胸外科,中国肺癌杂志编辑部
Subject
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