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外泌体在肺癌发病及诊断中作用的研究进展
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外泌体在肺癌发病及诊断中作用的研究进展
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外泌体在肺癌发病及诊断中作用的研究进展
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Journal Article
外泌体在肺癌发病及诊断中作用的研究进展
2020
Overview
世界范围内肺癌的发病率居高不下,不论男性还是女性,肺癌均是恶性肿瘤死亡的首位原因.肺癌的早期诊断将显著改善患者的预后,寻找辅助早期肺癌诊断的标志物是当前研究热点.外泌体是由各种细胞分泌的纳米级微囊泡,包含核酸、蛋白质和脂质等多种成分,是细胞间或细胞与组织间信号传递或物质运输的重要载体.独特的富集机制使其具有作为生物标志物的稳定性和特异性.外泌体除参与肺癌肿瘤微环境的形成及新生血管的生成外,还参与化疗、靶向治疗反应及预后评估.诸多研究进展成果为延长肺癌患者生存期带来新的希望.本文就外泌体特异性蛋白和微小RNA(microRNA,miRNA)在肺癌发病、诊断及预后评估中的价值进行综述.
