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GSDME介导的细胞焦亡在肺癌治疗中作用的研究进展
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GSDME介导的细胞焦亡在肺癌治疗中作用的研究进展
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GSDME介导的细胞焦亡在肺癌治疗中作用的研究进展
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Journal Article
GSDME介导的细胞焦亡在肺癌治疗中作用的研究进展
2024
Overview
目前肺癌对人类健康构成了巨大威胁.尽管有关肺癌的治疗技术近年有了显著提高,但肺癌患者的5年生存率仍然不高.在此背景下,细胞焦亡(pyroptosis)这一独特的细胞死亡机制的发现,为探索肺癌治疗的新途径提供了全新的视角.特别是成孔蛋白E(gasdermin E,GSDME)在细胞焦亡过程中扮演的角色,提示其在肺癌治疗中具有巨大的应用潜力.近年来,GSDME介导的细胞焦亡在肺癌生长、肺癌微环境中的调节作用及GSDME甲基化对肺癌治疗影响的研究取得了较大的进展,本文对这些研究进展进行了总结,并对GSDME介导的细胞焦亡在肺癌治疗中的潜力及潜在的副作用进行了分析,旨在为开发更有效的肺癌治疗策略提供理论基础.
Publisher
524023 湛江,广东医科大学生物化学与分子生物学研究所,抗肿瘤活性物质研发协同创新中心,523808 东莞,广东医科大学医学技术学院,Editorial board of Chinese Journal of Lung Cancer
Subject
