Asset Details
Do you wish to reserve the book?
Basic Science and Pathogenesis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Basic Science and Pathogenesis
Do you wish to request the book?
Basic Science and Pathogenesis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Basic Science and Pathogenesis
2024
Overview
Emerging studies have identified changes in lipid processing in Alzheimer's disease patients. However, how the various brain cell types respond to these changes is unclear. Multiple Alzheimer's disease risk genes are expressed in microglia and involved in lipid sensing and processing.
In this project, we assessed unbiasedly how various fatty acids impact microglia states and functions. Using the iPSC-derived microglia platform, our lab has recently developed (Dolan*, Therrien* et al. Nature Immunology 2023), we characterized the impact of 48 different fatty acids on human microglia.
We identified 5 distinct transcriptional signatures produced in response to various lipids, including a toxic lipotoxicity signature independent of TREM2 signaling. Using microglia villages, we assessed the toxicity across 25 iPSC donors and identified genetic modifiers of microglia lipotoxicity.
Together, our data identifies genetic regulators of microglia states and presents new insight into understanding how to protect synapses in Alzheimer's that could lead to new therapies and biomarkers for early diagnoses.
