Asset Details
Do you wish to reserve the book?
Clinical Manifestations
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Clinical Manifestations
Do you wish to request the book?
Clinical Manifestations
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Clinical Manifestations
2025
Overview
Recent work (Jack et al, 2024) proposes an AD diagnostic framework which moves biomarkers to the centre, proposing that short of biomarker access, clinicians should simply refer to patients as having \"dementia\" or \"MCI\" without further differentiation. Such a move would have a significant negative impact on all patients and physicians lacking access to diagnostic biomarkers, ignores their clinical acumen, and negates the considerable progress in clinical neurology over the past generation.
A review of the literature on clinical diagnosis was supplemented by database review of convenience sample of 52 subjects with clinical probable AD and known amyloid status (csf or PET), as well as 145 subjects from the Canadian COMPASS-ND dataset with known amyloid status (csf).
A proposal is made to continue diagnostic algorithms promoting distinction of dementia patients into those with and without motor features. A proposal is further made to refer to clinical \"AD phenotype\" dementia patients without motor features as having \"Alzheimer Syndrome\". A further level of diagnosis would consist of distinguishing Alzheimer Syndrome patients into those with and without presence of amyloid. This can be accomplished with about 80% accuracy using clinical guidelines such as CAPS (A Clinical beta Amyloid Positivity prediction Score; Lahiri et al, 2024) utilizing presence of neuropsychiatric features, rapidity of cognitive decline, and presence of white matter disease. Greater accuracy than this would require use of amyloid biomarkers.
Changes in terminology are now necessary to acknowledge the language proposed by the academic community which has easy access to biomarkers, without disempowering clinicians (most of them) who lack easy access to the biomarkers. Good (but not excellent) level of specifying likelihood of amyloid being present, can likely be achieved with more accessible clinical markers. This approach should be pursued and replicated among diverse populations of patients around the world.
