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Enhancement of Solubility of Leflunomide with β-cyclodextrin inclusion complexation
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Enhancement of Solubility of Leflunomide with β-cyclodextrin inclusion complexation
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Journal Article
Enhancement of Solubility of Leflunomide with β-cyclodextrin inclusion complexation
2021
Overview
4 mg/ 100 ml at 25°C), which limits its dissolution and consequently its bioavailability. [...]it is important to enhance the solubility and dissolution rate of Leflunomide to improve its oral bioavailability. Phase solubility analysis of Leflunomide: Phase solubility study was done to determine the stoichiometric proportion of Leflunomide with complexing agent ß-CD. Inclusion complexes prepared by kneading method showed higher saturation solubility than those prepared by other methods8,9. 3) IR spectral analysis: IR Spectra of pure drug and inclusion complexes of Leflunomide with ß-CD prepared by different methods are given in Fig. 1. The spectra of inclusion complexes and physical mixtures of components revealed disappearance of characteristic peaks of aromatic C-H stretching, N-H stretching and Amide at 3250 cm-1, 3400 cm-1 and 1670 cm-1respectively. [...]it suggests that vibrating and bending movements of guest molecule that is Leflunomide were restricted due to formation of inclusion complex.
Publisher
A&V Publications
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