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小檗碱治疗肾脏疾病研究现状
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小檗碱治疗肾脏疾病研究现状
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Journal Article
小檗碱治疗肾脏疾病研究现状
2020
Overview
R285.5; 肾脏是重要的新陈代谢器官,具有排泄废物、维持电解质及酸碱平衡、调控血压及内分泌等多种功能.肾脏疾病是危害人类健康的常见病,已成为全球范围内的公共卫生问题.肾病患者迅速增多及治疗费用昂贵给社会和家庭带来了沉重的负担.西药效果确切,在肾脏疾病的治疗中发展迅速,但使用不当可加重肾脏损害.近年来,中药及中药单体因具有多靶点、多通路的治疗优势,在肾脏病治疗中得到了广泛的认可和应用.小檗碱(BBR)是一种主要从中药黄连中提取的喹啉类生物碱,具有多种药理作用及出色的肾脏保护作用.BBR具有多靶点、多通路的治疗特性,在肾脏疾病的治疗中具有巨大的潜力.该文梳理了BBR的药理机制,主要从抗氧化应激、抗炎、降血糖、降血压、降血脂、抗肿瘤等方面论述,并结合BBR在糖尿病肾病、急性肾损伤等疾病治疗中的临床应用进行综述,以期为肾脏疾病的治疗提供新的思路,为中西医结合的发展奠定基础.
Publisher
广东药科大学临床医学院,广州 510000,解放军总医院第一医学中心肾脏病科/解放军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心,北京 100853%解放军总医院第一医学中心肾脏病科/解放军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心,北京 100853
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