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新型冠状病毒肺炎重症化的高危因素分析
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新型冠状病毒肺炎重症化的高危因素分析
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Journal Article
新型冠状病毒肺炎重症化的高危因素分析
2020
Overview
R373.1; 目的 探讨新型冠状病毒肺炎(COVID-19)重症化的高危因素,为精准诊疗提供依据.方法 回顾性分析2020年1月20日-2月13日于安徽阜阳市第二人民医院住院的COVID-19患者的临床资料,按照病情进展与否分为稳定组和重症化组,使用多因素COX比例风险回归分析及动态变化评估重症化的高危因素.结果 最终纳入143例COVID-19确诊患者,年龄43.5(32.7,52.4)岁,其中81例(56.6％)为男性,28例(19.6％)存在基础疾病.最常见的症状为发热[119例(83.2％)],其次为干咳[(77例(53.8％)].共有122例(85.3％)病情持续好转(稳定组),21例(14.7％)在出现症状2周内病情加重(重症化组).多因素COX比例风险回归分析显示,年龄>60岁(HR=3.5,95％CI 1.4～9.0)、合并基础疾病(HR=3.9,95％CI 1.5～10.4)、乳酸脱氢酶>250.0 U/L(HR=4.1,95％CI 1.4～12.6)、淋巴细胞绝对值<1.0×109/L(HR=6.8,95％CI 2.3～20.7)为COVID-19患者重症化的高危因素.结论 在COVID-19救治过程中明确其重症化高危因素有利于制定个体化、精准化的治疗方案.
Publisher
安徽省阜阳市第二人民医院肝脏病科二病区,安徽阜阳 236000%解放军总医院第五医学中心肝硬化诊疗二中心,北京 100039
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