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Effect of Olanzapine on A Model of Schizophrenia Induced yy Isolation Rearing in Male Sprague Dawley Rats
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Effect of Olanzapine on A Model of Schizophrenia Induced yy Isolation Rearing in Male Sprague Dawley Rats
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Journal Article
Effect of Olanzapine on A Model of Schizophrenia Induced yy Isolation Rearing in Male Sprague Dawley Rats
2018
Overview
Schizophrenia is a common clinical disorder of psychopathology. Olanzapine has proven efficacy to treat positive symptoms of schizophrenia with enhanced tolerability compared to older first generation antipsychotics. The present study was undertaken to explore the possible effects of olanzapine (6 mg/kg/day) on sociality and cognition in isolated reared rats as a model of schizophrenia. Results: It could be seen that sociality (SI)is deteriorated significantly in isolated reared rats which is very suggestive of induction of schizophrenia's negative symptoms and significantly improved by chronic administration of olanzapine to the extent of social reared (SR) group. Chronic administration of olanzapine obviously decreased cognition indicated by decreased (SPI), increased latency to reach target quadrant and decreased % of time spent in target quadrant day Conclusion: olanzapine had a beneficial effect on increasing sociality in isolated reared rats, but it deteriorates spatial memory and novel object recognition.
Publisher
المركز القومي للبحوث الاجتماعية والجنائية
Subject
