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Protective Effect of Echinacea \Echinacea Angustifolia\, Rosemary \Rosmarinus Officinalis, L.\ and Dandelion \Taraxacum Officinal\ Powder in Alloxan-Diabetic Rats
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Protective Effect of Echinacea \Echinacea Angustifolia\, Rosemary \Rosmarinus Officinalis, L.\ and Dandelion \Taraxacum Officinal\ Powder in Alloxan-Diabetic Rats
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Journal Article
Protective Effect of Echinacea \Echinacea Angustifolia\, Rosemary \Rosmarinus Officinalis, L.\ and Dandelion \Taraxacum Officinal\ Powder in Alloxan-Diabetic Rats
2022
Overview
This study was performed to assess the Protective effect of Echinacea (EP), Rosemary (RP) and Dandelion (DP) powder on body weight, blood glucose (BG), insulin, immune status, total cholesterol (TC), triglycerides (TG) and kidney function parameters as well as on activities of renal tissue antioxidant enzymes in diabetic rats. sixty three mature Sprague Dawley male rats were randomized into 6 main groups (n= 7) they are divided into sub-groups. Group (1) was used as a negative control and fed on basal diet, while the remaining 5 groups were rendered diabetic by intraperitoneal injection of alloxan (120 mg/kg). After induction of diabetes, group (2) was kept positive control, while groups (3), (4) ,(5) and (6) were divided into group A, B were fed on diet supplemented with 5% , 10% EP; RP; DP and 5% from ( EP+RP+DP) respectively for 10 weeks. Blood samples were collected for estimation of differential leucocytic count and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in kidney tissues. Insulin, TC and TG levels, blood urea nitrogen (BUN), uric acid and creatinine (Cr) serum levels were also determined. The results showed that diet supplementation with EP, RP and DP significantly increased body weight and improved feed efficiency ratio of diabetic rats. Diet supplementation with EP, RP and DP decreased the number of lymphocytes, production of TNF-α and cytokines IL4 and IL8; normalized BG, insulin, TC and TG and BUN and Cr levels. There were enhanced the activity of SOD, GPx and CAT enzymes in renal tissues of diabetic rats. In conclusion, diet supplementation with EP, RP and DP has immunostimulant, antidiabetic, hypolipidemic, nephroprotective andantioxidant activities in diabetic rats. Therefore, intake of extract of EP, RP and DP may be beneficial for patients who suffer from diabetes mellitus.
Publisher
جامعة المنصورة - كلية التربية النوعية
Subject
