Journal Article

Studying the Effect of Dark Coffee and its Extract on Protection from Hyperlipidemia in Rats

Salem, Ibrahim S, Ameen, Ahmed Ali, Ghareeb, Sharehan A

2024

Overview

Coffee contains more than 800 compounds known to have an impact on human health. The purpose of this study is to investigate how ground dark or green coffee or extracted coffee bean affects the serum lipid profile and other related parameters. Sixty eight Sprague Dawely rats were divided into 8 groups (n=8) as follows: Group 1: Negative control group (NC) was fed on basal diet during the experimental period. Group 2: Positive control group (PC), rats were fed on hypercholesterolemic diet solely. Group 3: Rats were fed on hypercholesterolemic diet containing 5% ground dark coffee beans. Group 4: Rats were fed on hypercholesterolemic diet containing 10% ground dark coffee beans. Group 5: Rats were fed on hypercholesterolemic diet with lower oral standard dose of dark coffee extracted beans (50 ml/ kg diet). Group 6: Rats were fed on hypercholesterolemic diet with the higher oral standard dose of dark coffee extracted beans (100 ml/ kg diet). Group 7: Rats were fed on hypercholesterolemic diet containing 5% ground green coffee beans. Group 8: Rats were fed on hypercholesterolemic diet containing 10% ground green coffee beans. It can be noticed that both dark or green ground coffee and extracts improved lipid profile, where decreased the total cholesterol, LDL-C, VLDL-C and triacylglycerol, however, increased HDL-C when compared to positive control group. Also they lowered the concentration of both uric acid and urea compared to positive control group. These findings indicated to the effect of consumption of coffee to improve lipid profile. To highlight our findings related to other research work we may find that the most research papers reported different doses of dark and green coffee or their extracts, different experimental animals and different sample size. Further studies are needed to include clinical trials.

• Publisher: جامعة الزقازيق - كلية التربية النوعية
• Subject: ارتفاع دهون الدم / بذور القهوة / مسحوق الكوليسترول / نظام غذائي