Journal Article

Comparison the Protective Effect of Bee Honey Alone or Combined with its Different Products against some Effects of Paracetamol Overdose in Rats

Elmesilhy, Shaimaa Mostafa, Nasef, Amal Z

2024

Overview

Paracetamol is a wide analgesic drug used without prescription especially after the COVID-19 pandemic without attention to its potential side effects and toxicities risks. Paracetamol overdose can cause oxidative organs injury mainly liver and kidney being the most difficult medical conditions increasing through the years especially in Egypt. Although bee products prolonged used as medicine in ancient Egypt due to their well-known health properties, there are a limited studies on clover honey. So, this study compared the protective effects of Egyptian clover honey, a cheap and popular type, alone or enhanced with 3% different bee products (propolis, pollen, royal jelly and their equal mix) (5g/kg b.w.) vs. silymarin (50 mg/kg b.w.) as antioxidant drug against some toxic effects of paracetamol overdose (650 mg/kg b.w.) in rats for 2 weeks. Also, honey chemical composition, total phenols and flavonoids and antioxidant activity plus sensory evaluation of jams made of honeys were done. Adding different bee products to honey enlargement its total phenols, antioxidant activity and nutritional profile as raises protein, ash, fat and fiber while carbohydrates were reduced. Enhanced honey with different bee products attenuated paracetamol oxidative and inflammation effects as nitric oxide and malondialdehyde reduction plus total antioxidant increase leading to reno-hepatoprotective with best effect for honey plus pollen and mix, while honey with royal jelly was the strongest uric acid lowering effect. Also, improvements in lipids profile and atherogenic indices were detected by best effects for honey with propolis and mix. Honey group results reached to healthy group and silymarin drug which is sometimes more effective. Additionally, jams sensory evaluation made of honey showed good acceptability, keeping its texture without smoothing the surface or saccharification indicating good technological properties than sucrose jam, plus lovely flavor of honey with pollen jam which is near to clove. Although enhanced honey can be used as it is or even added to the water for health purposes but including it within different foods enhances their consumption. These findings highlight the detoxified effects of supported Egyptian clover honey with different bee products against paracetamol toxicity which still need more specific searches to prove and detect the perfect type of honey and bee products, effective safe dose, form, and period toward these respects considering the variation in bioactive components and their mechanisms, plus new technological food applications.

• Publisher: جامعة طنطا - كلية التربية النوعية
• Subject: التأثيرات الوقائية / السمية الكبدية / العلاجات البديلة / فئران التجارب