Journal Article

Effect of avocado on lipid Profile of hypercholesterolemic rats

El-Zoghbi, Mohamed Sayed, Negm, Shaimaa Hassan Ahmed, El-Bannair, Nefisa Hassan, Fathy, Naglaa Mohamed

2011

Overview

Avocados is one of function food. The present study aimed to investigate the effect of Avocado fruit on Serum lipid profile, liver function as well as histopathological changes of liver. Thirty male albino rats were used in this study. Rats were divided into five main groups (n=6 rats of each), group (1) was fed on basal diet and used as a control negative. Group (2) fed on the hypercholesterolemic diet and used as a control positive. Groups (3), (4) and (5) fed on the hypercholesterolemic diet formulated with 2.5, 5 and 10% dried avocado, respectively. At the end of experiment, blood samples were taken for biochemical analysis, while livers were removed for histopathological examination. Results revealed that positive group had significant decreases in body weight gain (BWG) , fed efficiency ratio (FER) and serum HDL-c and significant increased in serum levels of total lipid (TL), total cholesterol (TC), triglycerides(TG), LDL-C,VLDL-c, AST and ALT compared to negative group. Hypercholesterolemic groups fed on different levels of avocado fruit had significant increased in food intake (except those treated with 2.5%), BWG, FER, and serum HDL- c while had significant decreased in serum levels of TL, TC, TG, LDL- c, VLDL- c, AST and ALT compared to positive group. The present study concluded that Avocado fruit had beneficial effects of lipid profile and lipoprotein levels as well as it improved liver and kidney functions in hypercholesterolemic rats

• Publisher: جامعة بورسعيد - كلية التربية
• Subject: الأغذية والصحة / الأفوكادو / العلاج بالتغذية / الكولسترول