Asset Details
Do you wish to reserve the book?
吸烟肺癌患者尿中烟草特有亚硝胺4-（甲基亚硝胺）-1-（3-吡啶）一1-丁酮代谢产物的测定
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
吸烟肺癌患者尿中烟草特有亚硝胺4-（甲基亚硝胺）-1-（3-吡啶）一1-丁酮代谢产物的测定
Do you wish to request the book?
吸烟肺癌患者尿中烟草特有亚硝胺4-（甲基亚硝胺）-1-（3-吡啶）一1-丁酮代谢产物的测定
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
吸烟肺癌患者尿中烟草特有亚硝胺4-（甲基亚硝胺）-1-（3-吡啶）一1-丁酮代谢产物的测定
2006
Overview
背景与目的国外研究表明不论以何种方式用烟草特有亚硝胺4-（甲基亚硝胺）-1-（3-吡啶）-1-丁酮[4-（methylnitrosamino）-1-（3-pyridyl）-1-butanone，NNK]处理小鼠均能特异地诱发小鼠肺癌，且多为肺腺癌，NNK是公认的吸烟者患肺癌的一个病因。本研究的目的是通过测定吸烟者尿中NNK的代谢产物4-（甲基亚硝胺）-1-（3-吡啶）-1-丁醇[4-（methylnitrosamino）-1-（3-pyridyl）-1-butanol，NNAL]及其解毒产物4-（甲基亚硝胺）-1-（3-吡啶-N-氧化物）-1-丁醇E4-（methylnitrosamino）-1-（3-pyridyl—N—oxide）一1一butanol，NNAL-Gluc]的含量及NNAL，Gluc／NNAL比值来了解NNK特异的致肺癌性。方法 用高压液相色谱仪（HPLC）和气相色谱-双极质谱联用仪（GC—Ms／MS）对10例吸烟肺癌患者、8例健康吸烟者和4例健康不吸烟者的24h尿样进行分析。结果 不吸烟者的尿中未测到NNAL和NNAL-Gluc，健康吸烟者尿中平均NNAL-Gluc／NNAL比值为4．95，吸烟肺癌患者为0．5。结论 建立了在吸烟者尿中测定NNK代谢产物NNAL及NNAL-Gluc的方法。初步研究显示健康吸烟者对NNK的解毒能力明显大于吸烟肺癌患者，为在吸烟人群中筛选肺癌高危人群提供了检测手段。
We currently cannot retrieve any items related to this title. Kindly check back at a later time.