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氧化苦参碱对慢性肾脏病患者血清TGF-β1和ColⅢ的影响
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氧化苦参碱对慢性肾脏病患者血清TGF-β1和ColⅢ的影响
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Journal Article
氧化苦参碱对慢性肾脏病患者血清TGF-β1和ColⅢ的影响
2008
Overview
目的观察氧化苦参碱对慢性肾脏病（CKD）患者血清转化生长因子-β1（TGF-β1）、Ⅲ型胶原（ColⅢ）的影响，探讨其在肾间质纤维化发生发展过程中的作用和治疗价值。方法选取健康对照者10例、慢性肾脏病患者40例，根据肾小球滤过率（GFR）分为轻度肾损害组（GFR〈90mL／min·1．73m^2，CKDI）、中重度肾损害组（GFR〈60mL／min·1．73m^2，CKDⅡ），再分层随机抽样，分为常规治疗组和氧化苦参碱组。利用双抗体夹心酶联免疫吸附法分别检测各研究对象治疗前、后血清TGF-β1、ColⅢ含量，采用t检验比较两组TGF-β1、ColⅢ水平的差异。站果氧化苦参碱组TGF-β1、ColⅢ含量显著低于常规治疗组（P〈0．05）。站论氧化苦参碱可能通过下调TGF-β1、ColⅢ水平，减少ECM沉积，从而达到防止肾间质纤维化的作用。
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