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甘氨酸对大鼠视皮层神经元突触后NR2A-及NR2B—NMDA受体功能的调制作用
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Journal Article
甘氨酸对大鼠视皮层神经元突触后NR2A-及NR2B—NMDA受体功能的调制作用
2008
Overview
旨在探讨甘氨酸对大鼠视皮层神经元突触后不同亚型NMDA受体功能的调制作用。采用脑片标本的全细胞膜片钳技术，记录大鼠视皮层Ⅱ／Ⅲ层锥体神经元的微小兴奋性突触后电流（mEPSC）；灌流不同浓度甘氨酸和D-丝氨酸后，观察其对突触后NMDA受体电流的影响，之后使用NR2A—NMDAR和NR2B-NMDAR拮抗剂，观察其对突触后NMDA受体电流（NMDAR-mEPSC）的影响。结果表明：甘氨酸和D-丝氨酸均能增强mEPSC的NMDA受体成分，并呈现一定的浓度依赖性；
