Asset Details
Do you wish to reserve the book?
AF-2364，一种杀精子剂候选成分
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
AF-2364，一种杀精子剂候选成分
Do you wish to request the book?
AF-2364，一种杀精子剂候选成分
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
AF-2364，一种杀精子剂候选成分
2010
Overview
通过靶向作用于精子线粒体，抑制精子运动进行避孕是一种作用特异的、很有前景的避孕方式。AF-2364，是氯尼达明（Londidamine，LND）的类似物，其毒副作用显著降低，目前被认为是一种很有潜力的男性避孕的候选化合物。LND亦可作用于肿瘤细胞线粒体抑制能量代谢。目前尚无AF-2364对于人类精子功能作用的相关报道。在本研究中，我们探寻了AF-2364的体外杀精子作用及其初步机制。体外实验显示，AF-2364显著抑制人类精子的运动：进一步的研究发现，AF-2364可作用于精子线粒体膜通透性转换（PT）孔，降低线粒体膜电位（mitochondrial membrane potential，△ψm），抑制线粒体能量代谢，使ATP下降，从而使精子制动。我们同时检测了AF-2364作用后细胞骨架一系列蛋白调控通路在人精子中的变化及人精子蛋白组学改变，未见显著差异；AF-2364与人及小鼠其他细胞系孵育实验提示较低浓度下的AF-2364对人精子制动作用的特异性。综上，AF-2364可通过对精子线粒体PT孔的直接作用使精子制动，并可能发展为一种杀精子剂的候选成分。
Subject
