Journal Article

Hypoxla inducible factor 1 （HIF-1） and cardioprotection

Demet TEKIN Ali D DURSUN Lei XI

2010

Overview

Since its discovery in early 1990s, hypoxia inducible factor 1 （HIF-1） has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH regulation, cell proliferation and viability. Evidence accumulated during the past 7 years suggests a critical role for HIF-1α in mediating cardioprotection. The purpose of our present article is to provide an updated overview on this important regulator of gene expression in the cellular stress-responsive and adaptive process. We have particularly emphasized the involvement of HIF-1 in the induction of cardioprotective molecules, such as inducible nitric oxide synthase （iNOS）, hemeoxygenase 1 （HO-1）, and erythropoietin （EPO）, which in turn alleviate myocardial damages caused by harmful events such as ischemia-reperfusion injury. Despite these advances, further in-depth studies are needed to elucidate the possible coordination or interaction between HIF-1α and other key transcription factors in regulating protein expression that leads to cardiopro- tection.

• Subject: 促红细胞生成素 / 心肌保护 / 缺氧诱导因子1 / 缺血再灌注损伤 / 血管生成 / 血红素加氧酶 / 诱导型一氧化氮合酶 / 转录调控