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正常骨髓基质细胞促进残留耐药Jurkat细胞凋亡的研究
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正常骨髓基质细胞促进残留耐药Jurkat细胞凋亡的研究
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Journal Article
正常骨髓基质细胞促进残留耐药Jurkat细胞凋亡的研究
2011
Overview
目的探讨正常骨髓基质细胞对残留耐药Jurkat细胞凋亡的促进作用及其可能机制。方法体外分离培养急性淋巴细胞白血病患者和健康供者骨髓基质细胞（BMSCs）,分别模拟白血病和正常骨髓造血微环境,并与获得柔红霉素（DNR）耐药的Jurkat细胞（Jurkat/DNR细胞）共培养。绘制悬浮培养和与BMSCs共培养4d的Jurkat/DNR细胞的增殖曲线,并检测悬浮培养及共培养14、1、0d的Jurkat/DNR细胞的caspase3/7活性和bcl-2、bax、DAPK1 mRNA表达情况。结果与骨髓基质细胞共培养比较,悬浮培养的Jurkat/DNR细胞生长受到明显抑制。共培养41、0d后,Jurkat/DNR细胞caspase3/7活性升高,且共培养10d的活性高于共培养4d（P〈0.05）。共培养4、10d后,Jurkat/DNR细胞bcl-2表达增加,共培养14、1、0d后,死亡相关蛋白激酶1（DAPK1）表达增加（P〈0.05）。而bax表达在各时间点间差异无统计学意义（P〉0.05）。结论正常骨髓基质细胞能促进Jurkat/DNR凋亡,其机制可能与过表达的DAPK1诱导Jurkat/DNR细胞凋亡和bcl-2转录下调c、aspase3/7活性升高有关。
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