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New WHO-reference limits--revolution or storm n a teapot
by
Gerhard Haidl
in
世卫组织
/ 分类标准
/ 功能试验
/ 生物标志物
/ 生育能力
/ 蛋白质组学
2011
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New WHO-reference limits--revolution or storm n a teapot
by
Gerhard Haidl
in
世卫组织
/ 分类标准
/ 功能试验
/ 生物标志物
/ 生育能力
/ 蛋白质组学
2011
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Journal Article
New WHO-reference limits--revolution or storm n a teapot
2011
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Overview
Since release of the latest WHO manual with the new lower reference values of semen parameters, a lot of discussion has been raised about their usefulness and appropriateness for assessment of male fertility. As with the previous reference values the new limits do neither allow an andrological diagnosis based on nosological criteria nor clear-cut differentiation between fertility and sub-/infertility. Therefore, considering the fact that fertility is a continuum, the new lower reference limits should not be overestimated. Most probably, more sperm function tests, such as determination of DNA integrity, and--in the future--assessment of biomarkers, such as sperm proteomics will be included into andrological work-up, thus resulting in a more personalized approach of infertility management. On the other hand, the detailed instructions for standard and advanced semen analysis provided in the new manual are very much appreciated and should be adopted by each seriously workin~ laboratory.
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