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肺肿瘤演进中cyclinD1、p53基因表达的实验研究
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肺肿瘤演进中cyclinD1、p53基因表达的实验研究
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Journal Article
肺肿瘤演进中cyclinD1、p53基因表达的实验研究
2002
Overview
目的：探讨乙酰胆蒽（20-MC)诱导小鼠肺肿瘤发生、发展过程中cyclinD1和p53基因表达特点及其意义。方法：小鼠腹腔内注射20－MC，在不同时间段处死小鼠，得到肺部病变共292个，其中上皮增生（HP）31个，肺泡细胞腺瘤（AA）145个，乳头状腺瘤（PA）61个，乳头状腺癌（PC）55个及其复合性病变。应用免疫组化法检测各型病变中cyclinD1、p53基因蛋白表达情况。结果：cyclinD1癌基因蛋白在HP、AA、PA及PC中均有表达，分别为86％（6／7）、87％（89／102）、73％(41／56）及68％（17／25），cyclinD1癌基因蛋白在良性病变的表达强于恶性病变（x^2=5．531，P＝0．033）。p53抑癌基因蛋白表达于腺癌组织、有明显异型性的细胞、肿瘤进展较晚期，PC、PA和AA阳性率分别为40％（16／40）、9％（6／69）和3％（4／121），且分布方式不同，HP无表达。癌组织中p53基因表达明显强于各良性病变（x^2＝41．77，P＝0．000），各型病变中以PC的cyclinD1、p53基因均阳性的比率较高,为26％，HP和AA中两基因无共同表达。结论：cyclinD1基因可能参与调控肺肿瘤发生过程，而p53抑癌基因突变则与细胞增恶、肿瘤进展等有密切关系。
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