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肾功能损害标志物测定在慢性肾脏病诊断中的临床价值
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Journal Article
肾功能损害标志物测定在慢性肾脏病诊断中的临床价值
2011
Overview
目的研究慢性肾脏病（CKD）患者肾功能损害标志物水平的变化,评价其在CKD诊断中的意义。方法研究对象共66例,其中病例组（CKD患者）37例,对照组29例。采用谷氨酸脱氢酶法检测血清尿素氮（SBUN）浓度,肌氨酸氧化酶法测定血清肌酐（SCr）和尿肌酐（UCr）含量,尿酸酶比色法测定血清尿酸（SUA）含量。免疫透射比浊法分析受试者血清胱抑素C（Cys C）和尿微量白蛋白（UmAlb）水平,考马斯亮蓝（CBB）法测定尿蛋白（U-PRO）含量。UmAlb、U-PRO水平均以mg/mmolUCr为单位表示。结果独立样本t检验结果表明,病例组与对照组比较,SBUN、SCr、SUA、Cys C、UmAlb和U-PRO差异有统计学意义（P〈0.05）。诊断效果评价表明,SBUN、SCr、SUA、Cys C、UmAlb和U-PRO在ROC曲线下的面积分别为0.907、0.912、0.742、0.982、0.984和0.991。结论在评价CKD患者肾功能损害及其程度时,以U-PRO、UmAlb和Cys C为最佳,SCr、SBUN次之,SUA居后。
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