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Glucagon-Iike peptide I receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells
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Glucagon-Iike peptide I receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells
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Glucagon-Iike peptide I receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells
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Journal Article
Glucagon-Iike peptide I receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells
2012
Overview
Aim： To explore the role of the glucagon-like peptide 1 receptor （GLP-1R） in geniposide regulated insulin secretion in rat INS-1 insulinoma cells.
Methods： Rat INS-1 insulinoma cells were cultured. The content of insulin in the culture medium was measured with ELISA assay. GLP-1R gene in INS-1 cells was knocked down with shRNA interference. The level of GLP-1R protein in INS-1 cells was measured with Western blotting.
Results： Geniposide （0.01-100 pmol/L） increased insulin secretion from INS-1 cells in a concentration-dependent manner. Geniposide （10 pmol/L） enhanced acute insulin secretion in response to both the low （5.5 mmol/L） and moderately high levels （11 mmol/L） of glucose. Blockade of GLP-1R with the GLP-1R antagonist exendin （9-39） （200 nmol/L） or knook-down of GLP-1R with shRNA interfer- ence in INS-1 cells decreased the effect of geniposide （10 IJmol/L） on insulin secretion stimulated by glucose （5.5 mmol/L）.
Conclusion： Geniposide increases insulin secretion through glucagon-like peptide 1 receptors in rat INS-1 insulinoma cells.
