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白藜芦醇对小鼠胰岛样细胞团的抗移植排斥作用及其IL-2、IL-10表达的影响
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白藜芦醇对小鼠胰岛样细胞团的抗移植排斥作用及其IL-2、IL-10表达的影响
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白藜芦醇对小鼠胰岛样细胞团的抗移植排斥作用及其IL-2、IL-10表达的影响
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Journal Article
白藜芦醇对小鼠胰岛样细胞团的抗移植排斥作用及其IL-2、IL-10表达的影响
2012
Overview
目的探讨白藜芦醇（Res）对小鼠胰岛样细胞团（ICCs）的抗移植排斥作用及相关细胞因子表达的影响。方法采用BALB/c小鼠胚胎干细胞系B/c-ES在体外定向诱导形成ICCs,DIPA标记后移植至近交系昆明小鼠皮下。将小鼠随机分为环孢素A（CsA）组（阳性对照）、Res组、CsA＋Res组和PBS组（阴性对照）,每组6只,移植前3d开始给药（CsA及Res剂量均为50mg/kg）,每天1次直至取材日。分别于ICCs移植后第5天和第10天取移植物常规病理切片,观察免疫排斥情况,部分切片行免疫组化染色,检测IL-2、IL-10表达情况。结果移植后第5天各组均出现不同程度的移植排斥反应,除不用免疫抑制剂的PBS组外,其余各组均有移植细胞存活;Res组和CsA＋Res组IL-2表达率分别为17.5%及14.5%,明显低于CsA组（59.5%,P〈0.05）,而Res组与CsA＋Res组比较差异无统计学意义（P〉0.05）;Res组和CsA＋Res组IL-10阳性表达率（分别为23%和48%）明显高于CsA组（12.5%,P〈0.05）,且CsA＋Res组明显高于Res组（P〈0.05）。移植后第10天,仅CsA＋Res组有少量移植细胞存活,其余各组未见移植细胞;CsA组IL-2和IL-10表达明显减弱,其余各组几乎不表达IL-2和IL-10。结论 Res可抑制小鼠ICCs移植后的急性排斥反应,其机制可能与下调IL-2表达及上调IL-10表达有关。
