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Journal Article
育龄期妇女月经紊乱与卵巢储备功能下降的关系
2012
Overview
目的探讨育龄期妇女月经紊乱症状与卵巢储备功能下降的关系。方法回顾分析2009年11月-2011年8月收治的282例育龄妇女的临床资料,其中对照组101例,均为月经正常者,月经紊乱组181例,均为近1年出现月经紊乱患者。月经紊乱组按月经紊乱持续时间长短分为3个亚组：A组（n=47）,月经紊乱持续1-4个月,B组（n=59）,月经紊乱持续5-8个月,C组（n=75）,月经紊乱持续9-12个月;按月经改变类型分为4个亚组：组1（n=62）,经量减少;组2（n=27）,经量增多;组3（n=35）,周期缩短;组4（n=57）,周期延长。比较对照组与月经紊乱组间,A、B、C 3个亚组之间年龄、血清卵泡刺激素（FSH）、血清促黄体生成素（LH）、血清雌二醇（E2）、FSH/LH比值和窦卵泡（AFC）数目,并比较组1、组2、组3、组4上述指标与对照组的差异。结果月经紊乱组的年龄、基础FSH水平、FSH/LH比值均明显高于对照组（P〈0.05）,AFC数目则低于对照组（P〈0.05）;月经紊乱组A、B、C 3个亚组的年龄、FSH值、LH值、FSH/LH比值、AFC数目比较差异均有统计学意义（P〈0.05）,且随着月经紊乱持续时间的延长,年龄、FSH值、FSH/LH比值呈上升趋势,LH值和AFC数目呈下降趋势;组1、组2、组4的FSH值与对照组比较均有统计学意义（P〈0.05）,4个亚组的FSH/LH比值与对照组比较均明显升高（P〈0.05）,而AFC数目均明显降低（P〈0.05）,以组3为最低。结论月经紊乱育龄期妇女卵巢储备功能可能已下降,月经紊乱持续时间及月经周期改变可作为育龄妇女卵巢储备功能下降的敏感信号。
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