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自体骨髓干细胞联合脐血单个核细胞移植治疗胸段慢性脊髓损伤27例报告
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自体骨髓干细胞联合脐血单个核细胞移植治疗胸段慢性脊髓损伤27例报告
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Journal Article
自体骨髓干细胞联合脐血单个核细胞移植治疗胸段慢性脊髓损伤27例报告
2012
Overview
目的观察自体骨髓干细胞联合脐血单个核细胞移植治疗胸段慢性脊髓损伤的效果。方法选择接受自体骨髓干细胞联合脐血单个核细胞移植治疗的胸段慢性脊髓损伤患者27例，每位患者均接受4次干细胞悬液注射治疗，每周1次。收集患者治疗前（基线）及治疗后6周、6个月时的最低正常功能平面，ASIA残损分级，ASIA运动感觉评分，ASIA模拟视觉评分，Ashworth评分等资料并进行比较，评价治疗效果。结果治疗后6个月，6例患者左、右侧感觉最低正常功能平面出现下降（1或2个平面），s例患者两侧运动最低正常功能平面出现下降（下降1个平面2例，2个平面1例，10个平面l例，11个平面1例）。治疗后6周，ASIA残损分级由A级变为B级4例，由A级变为C级1例，由B级变为C级1例，ASIA残损分级变化率为22．2％（6／27）；治疗后6个月随访时，ASIA残损分级由A级变为B级1例，ASIA分级总的变化率为25．9％（7／27）。治疗后6周、6个月tCASIA下肢运动评分分别为1．7±2．9、3．1±3．6，明显高于治疗前（0．5±1．5，P〈0．05）。治疗后6周、6个月时ASIA感觉（轻触）评分分别为68．8±14．4、70．5±14．4，ASIA感觉（针刺）评分分别为68．4±14．7、70．2±14．4，均明显高于治疗前（分别为66．6±13．7、67．0±13．6，P〈0．05）。治疗前改良Ashworth量表评分为1．8±1．5，与治疗后6周（1．6±1．2）比较无明显差异，但明显高于治疗后6个月（1．1±0．8，P〈0．05）。结论自体骨髓干细胞联合脐血单个核细胞移植能从一定程度上改善胸段慢性脊髓损伤患者ASIA残损分级和运动感觉功能，并可部分促进慢性脊髓损伤的恢复。
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