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耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究
耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究
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耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究
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耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究
耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究

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耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究
耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究
Journal Article

耐药性癫痫患者脑脊液HSPBAP1和EML5表达变化的临床研究

2012
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Overview
目的观察热休克蛋白27相关蛋白1(HSPBAPl)和棘皮动物微管结合蛋白类似蛋白5(EML5)在耐药性癫痫患者脑脊液中的表达变化,探讨其用于耐药性癫痫早期诊断的临床价值。方法根据纳入标准共选择39例耐药性癫痫患者和性别、年龄与之相匹配的健康志愿者40例入组,经腰椎穿刺术采集脑脊液标本,双抗体夹心酶联免疫吸附法检测HSPBAPl和EML5。结果耐药性癫痫组患者脑脊液HSPBAP1和EML5表达水平分别为(0.17±0.03)和(0.13±0.02),正常对照组为(0.10±O.03)和(O.08±0.02),低于耐药性癫痫组且差异具有统计学意义(t=3.239,3.294;均P:O.002)。结论耐药性癫痫患者脑脊液HSPBAPl和EML5表达水平明显升高,可为耐药性癫痫的诊断提供新的途径,有助于耐药性癫痫的早期诊断。

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