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经典型热射病大鼠恢复期体温变化与预后的关系
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Journal Article
经典型热射病大鼠恢复期体温变化与预后的关系
2013
Overview
目的 构建经典型热射病（HS）大鼠模型，观察恢复期核心体温的调节特征，并分析其与预后的关系。方法 雄性SPF级SD大鼠60只随机分为HS组（n=50）和正常对照组（n=10）。HS组大鼠予39℃热打击，监测核心体温及动脉收缩压（SBP）变化，达到HS诊断标准后结束热打击，观察72h恢复期核心体温的变化特征及生存情况，并对预后因素进行单因素和多因素Cox回归分析。结果 HS组大鼠在热打击后恢复期表现为双相式变化，即发生低体温和迟发性高热。单因素分析显示，HS大鼠最高核心体温、最低核心体温均与预后相关（P〈0.05）。多因素分析显示，HS大鼠最高核心体温（P=0.000，HR=102.386）、恢复期最低核心体温（P=0.001，HR=0.134）为影响HS大鼠预后的独立危险因素。结论 大鼠达到HS时核心体温越高，其发生低体温的程度越深，预后越差。热应激期和恢复期核心体温水平可作为HS大鼠预后的敏感指标。
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