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肥胖对临床局限性前列腺癌患者临床病理特征的影响
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Journal Article
肥胖对临床局限性前列腺癌患者临床病理特征的影响
2013
Overview
本研究旨在探讨不同肥胖测量指标对中国临床局限性前列腺癌患者临床病理特征的影响。本研究共入组734例在我院接受根治性前列腺切除术治疗的临床局限性前列腺癌患者，我们回顾性收集了全组患者的临床病理资料。BMI的计算即体重公斤数除以身高米数的平方。本组共413例患者术前在我院行盆腔增强核磁共振（magnetic resonance imaging，MRI）扫描。在MRJ扫描T2加权、矢状位图像上测量413例患者的腹部肥胖测量指标。利用方差分析或卡方检验比较不同BMI组患者的临床病理特征。利用Logistic回归模型分析术前血清睾酮水平和各肥胖测量指标对术后病理结果的影响。在多因素分析中，我们并未发现BMI与患者术后病理结果存在相关性。然而，多因素分析结果显示，内脏脂肪比例为术后病理Gleason评分≥8分（P〈O．001），包膜外侵犯（P=0．002）和精囊腺侵犯（P=0．007）的独立预后因素。此外，我们还发现术前血清睾酮水平与内脏脂肪比例呈负相关（R=-0．485，P〈0．001）而与皮下脂肪厚度成正相关（R=0．413，P〈0．001）。综上所述，本研究结果显示，腹部脂肪的分布，尤其是内脏脂肪比例，是进展性前列腺癌的危险因素。而且，内脏脂肪比例与血清睾酮水平呈负相关。内脏肥胖影响进展性前列腺癌的分子生物学机制仍需进一步研究。
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