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新城疫病毒对CCl4诱导的小鼠肝纤维化的抑制作用研究
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新城疫病毒对CCl4诱导的小鼠肝纤维化的抑制作用研究
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Journal Article
新城疫病毒对CCl4诱导的小鼠肝纤维化的抑制作用研究
2013
Overview
目的观察新城疫病毒（NDV）对CCl4诱导的小鼠肝纤维化的抑制作用。方法昆明小鼠腹腔注射CCl4／花生油溶液，每周2次，连续8周，制作肝纤维化模型。最后一次CCl4注射后3d由尾静脉注射NDV1次或3次，每次注射间隔24h，注射完毕24h后处死动物。取出肝脏进行大体形态观察，行HE和天狼猩红染色观察肝组织病理学改变，Westernblotting检测肝组织中仪．平滑肌肌动蛋白（01．SMA）的表达。结果CCl4诱导8周后，小鼠肝脏出现明显纤维化表现，可见肝脏质硬、表面粗糙不平、大量密集分布的白色点状斑块。HE染色显示纤维化肝脏组织结构松散，窦周隙增大。天狼猩红染色显示胶原异常沉积。而NDV注射3次后，小鼠肝脏表面白色斑点显著减少，胶原沉积降低。Western blotting结果表明，α-sMA表达水平随NDV注射次数增加而降低。结论NDv能有效抑制CCl4诱导的小鼠肝纤维化的发生发展。
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