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心脏发育的信号调控与先天性心脏病的关系
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Journal Article
心脏发育的信号调控与先天性心脏病的关系
2013
Overview
心脏发育起源于原肠胚阶段位于前侧板中胚层的生心区，生心区祖细胞在特异细胞因子、诱导信号及核心转录因子构成的调控网络作用下分化为心肌前体细胞，心脏发育过程中的基因变异或发育环境变化可影响调控网络中的多个环节，最后导致先天性心脏病的发生。因此，研究心脏发育过程中的信号调控机制对于探讨先天性心脏病的发生机制具有重要的理论及临床意义。目前研究证实Nkx2．5、GATA4、Tbx5、lsl-1等众多早期转录因子均参与了心脏发育的基因调控网络，但网络中大部分信号通路的研究尚不深入。本文就目前研究较多的心肌前体细胞、Nkx2．5、GATA4、Tbx5、Isl．1等转录因子以及Apelin／APJ信号通路的近期研究进展作一简要综述。
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