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Full screening and accurate subtyping of HLA-A＊02 alleles through group-specific amplification and mono-allelic sequencing
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Full screening and accurate subtyping of HLA-A＊02 alleles through group-specific amplification and mono-allelic sequencing
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Journal Article
Full screening and accurate subtyping of HLA-A＊02 alleles through group-specific amplification and mono-allelic sequencing
2013
Overview
HLA-A＊02 is the most prevalent and polymorphic major histocompatibility complex （MHC） allele family in humans. Functional differences have been revealed among subtypes, demanding further subtyping of HLA-A＊02 in basic and clinical settings. However, the fast growing polymorphisms render traditional primeror probe-based typing methods impractical and result in increasing ambiguities in direct sequence-based typing. In this study, we combined group-specific amplification and mono-allelic sequencing to design and validate a simple scheme for the complete screening and accurate subtyping of all 540 reported HLA-A＊02 alleles. This scheme could be performed in routine labs to facilitate studies with an interest in HLA-A＊02.
