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齐留通对大鼠心肌缺血再灌注炎症损伤的抑制作用观察
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Journal Article
齐留通对大鼠心肌缺血再灌注炎症损伤的抑制作用观察
2014
Overview
目的探讨5-脂氧合酶（5-CO）选择性抑制剂齐留通（zileuton）对缺血再灌注心肌的保护作用及其可能机制。方法健康成年雌性SD大鼠30只，随机分为假手术组（s组，g／=10）、缺血再灌注组（I／R组，n=10）、齐留通组（Z组，n=10），采用结扎前降支造成缺血45min、松开结扎线灌注120min的方法建立缺血再灌注模型。Z组于手术前15min给予3mg／kg齐留通。再灌注结束后处死动物，HE染色观察心肌的病理损伤情况，TUNEL法检测心肌细胞凋亡率，ELISA法检测血浆中白三烯B4（LTB4）、IL-1p、TNF-a的含量，Westernblotting和免疫荧光法检测中性粒细胞中的5-LO分布变化。结果与I／R组比较，齐留通处理可以明显减轻缺血再灌注所致的心肌病理损伤，降低心肌细胞凋亡率，降低血浆中炎症因子LTB4、IL-1p和TNF-d的水平，抑Ns-LO的激活转位，差异有统计学意义（P〈0．05），但各组5-LO表达总量无明显差异（P〉0．05）。结论齐留通对缺血再灌注心肌具有一定的保护作用，其机制可能与抑制5-LO转位激活，进而减轻炎症损伤、抑制心肌凋亡有关。
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