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急进高原环境对血管内皮功能的影响及其与急性高原病的关系
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急进高原环境对血管内皮功能的影响及其与急性高原病的关系
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Journal Article
急进高原环境对血管内皮功能的影响及其与急性高原病的关系
2015
Overview
目的观察人群急进高原后血管内皮功能相关指标的变化,并探讨其与急性高原病（AMS）的关系。方法在平原地区招募32名受试者,以汽车方式急进高原（海拔3900m）。进入高原第5天根据路易斯湖量表评分,将受试者分为AMS＋组（n=14）和AMS–组（n=18）。ELISA法检测人群血清一氧化氮（NO）、内皮素-1（ET-1）、血管内皮生长因子（VEGF）、血管内皮钙黏蛋白（VE-cadherin）、丙二醛（MDA）及超氧化物歧化酶（SOD）等指标的变化。采用Pearson相关法分析上述指标与AMS的关系。结果急进高原后第5天时32名受试者中AMS的发生率为43.8%。与平原相比,受试者急进高原后血清NO、SOD水平明显降低（P〈0.05,P〈0.01）,ET-1和MDA水平明显升高（P〈0.05）。与AMS–人群比较,AMS＋人群NO、VEGF和VE-cadherin、SOD水平均明显降低（P〈0.05,P〈0.01）,ET-1水平明显升高（P〈0.01）。相关性分析显示,急性高原暴露第5天人群血清NO、VEGF、VE-cadherin、SOD水平与AMS呈显著负相关,ET-1水平与AMS呈显著正相关。结论急进高海拔环境可能导致血管内皮功能受损,血管内皮功能相关指标的变化可能为AMS的预警及诊断提供参考。
