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间充质干细胞培养上清输注对糖尿病大鼠治疗作用的机制研究
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间充质干细胞培养上清输注对糖尿病大鼠治疗作用的机制研究
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间充质干细胞培养上清输注对糖尿病大鼠治疗作用的机制研究
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Journal Article
间充质干细胞培养上清输注对糖尿病大鼠治疗作用的机制研究
2015
Overview
目的观察间充质干细胞（MSCs）培养上清输注对糖尿病大鼠高血糖紊乱的治疗效果,探讨MSCs分泌产物促进胰岛再生的作用机制。方法 SD大鼠腹腔单次注射大剂量链脲佐菌素（STZ,65mg/kg）建立糖尿病大鼠模型,将诱导成功的30只糖尿病大鼠随机分为MSCs培养上清治疗组（CM,n=15）、培养基治疗组（M,n=15）,分别输注MSCs培养上清、培养基。另将15只正常大鼠作为对照组。连续治疗3d后每日测血糖,于治疗第7天测定血清胰岛素及C肽,并行腹腔糖耐量检查（IPGTT）。对动物胰腺组织标本行多重免疫荧光染色,观察MSCs上清治疗后胰岛β细胞再生情况,并进一步探究胰岛细胞再生的可能机制。结果与M组比较,治疗早期（〈7d）CM组糖尿病大鼠血糖降低,血清胰岛素及C肽含量明显增加（P〈0.05）。IPGTT结果显示,CM组较M组糖尿病大鼠胰岛功能明显增强。胰腺组织多重免疫荧光染色提示,CM组糖尿病大鼠的胰岛内β细胞数量较M组明显增加（P〈0.05）,但仍少于对照组;β细胞增殖率较M组及对照组均显著提高（P〈0.01）。结论 MSCs分泌产物通过促进胰岛β细胞增殖,促进胰腺再生,恢复胰岛功能,可用于早期糖尿病的控制与治疗。
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