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脾脏^18F-FDG摄取在急性放射病中的诊断价值
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脾脏^18F-FDG摄取在急性放射病中的诊断价值
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Journal Article
脾脏^18F-FDG摄取在急性放射病中的诊断价值
2015
Overview
目的探讨18F-FDG摄取值是否可作为评估核事故后个体受照射剂量的快速精确测定方法。方法将48头西藏小型猪随机分为6个剂量组,分别为0、1、2、5、8、11Gy组。除0Gy组（对照组）外,其余组均接受全身8MV X线离心线性加速器照射。照射前与照射后6、24、72h实施全身18F-FDG PET/CT检查,收集脾脏组织用于组织病理学与凋亡检测;收集血液标本进行外周血分析。结果实验组与对照组的脾脏18F-FDG摄取值差异有统计学意义（P〈0.05或P〈0.01）。照射后6h,脾脏18F-FDG摄取值与照射剂量存在显著相关性,相关系数为0.95（P〈0.01）。组织病理学观察显示脾脏组织损伤程度与所接受的放射剂量呈正比。流式细胞学结果表明脾脏淋巴细胞损伤以凋亡为主。结论在西藏小型猪放射线损伤模型中,脾脏18F-FDG摄取与照射剂量密切相关,18F-FDG PET/CT可用于急性放射病后个体照射剂量的快速评估。
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