Asset Details
Do you wish to reserve the book?
High salt primes a specific activation state of macrophages, M（Na）
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
High salt primes a specific activation state of macrophages, M（Na）
Do you wish to request the book?
High salt primes a specific activation state of macrophages, M（Na）
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
High salt primes a specific activation state of macrophages, M（Na）
2015
Overview
High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and pro- endocytic molecules in both human and mouse macrophages. High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation. High salt induced the proinflammatory aspects by activating p38/cFos and/or Erkl/2/cFos pathways, while inhibited the anti-inflammatory and proendocytic aspects by Erkl/2/signal transducer and activator of transcription 6 pathway. Consistent with the in vitro results, high-salt diet increased proinflammatory gene expression of mouse alveolar macrophages. In mouse models of acute lung injury, high-salt diet aggravated lipopolysaccharide-induced pulmonary macrophage activation and inflammation in lungs. These results identify a novel macrophage activation state, M（Na）, and high salt as a potential environmental risk factor for lung inflammation through the induction of M（Na）.
We currently cannot retrieve any items related to this title. Kindly check back at a later time.