Journal Article

unctional metabolomics： from biomarker ：liscovery to metabolome reprogramming

Bo Peng Hui Li Xuan-Xian Peng

2015

Overview

Metabolomics is emerging as a powerful tool for studying metabolic processes, identifying crucial biomarkers responsible for metabolic characteristics and revealing metabolic mechanisms, which construct the content of discovery metabolomics. The crucial biomarkers can be used to reprogram a metabolome, leading to an aimed metabolic strategy to cope with alteration of internal and external environments, naming reprogramming metabo- Iomics here. The striking feature on the similarity of the basic metabolic pathways and components among vastly different species makes the reprogramming metabolomics possible when the engineered metabolites play biological roles in cellular activity as a substrate of enzymes and a regulator to other molecules including proteins. The reprogramming metabolomics approach can be used to clarify metabolic mechanisms of responding to changed internal and external environmental factors and to estab- lish a framework to develop targeted tools for dealing with the changes such as controlling and/or preventing infec- tion with pathogens and enhancing host immunity against pathogens. This review introduces the current state and trends of discovery metabolomics and reprogramming metabolomics and highlights the importance of repro- gramming metabolomics.

• Subject: 代谢机制 / 代谢组学 / 代谢过程 / 免疫增强作用 / 活性代谢产物 / 生物学作用 / 生物标志物 / 重新编程